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Objective To explore the over-expression of the CCAAT enhancer binding proteinα(C/EBPα)in hepatic stellate cells (HSC-T6) which activated by protease-activated receptor 1(PAR1) ,to explore its possible relationship with cell proliferation ,cell activation and collagen secretion of HSC-T6 cell .Methods HSC-T6 cells were divided into 4 groups ,control group ,SFLLR group;vehicle plasmid+SFLLR group ,C/EBPαplasmid+SFLLR group .The eukaryotic vector harboring the full length of C/EBPαcD-NA was transfected into PAR1 activated HSC-T6 cell ,then Western blot was applied to detect the expression of α-smooth muscle actin(α-SMA) and collagen I and evaluate the effect of transfection on proliferation of HSC-T6 by MTT .Results The expression of α-SMA and collagen I in C/EBPαplasmid+SFLLR group were dramatically decreased compared with other 3 groups ,as well as proliferation after 48 h(P<0 .05) .Conclusion Over-expression of C/EBPαgene by transfection had inhibitory influence on prolif-eration ,activation and collagen secretion of HSC-T6 which were activated by PAR1 .
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Objective We invented mammary lump skin-positioning membrane (named scare membrane) to facilitate localization of mammary lump during ultrasound scan.This study is to measure the radius of mammary of Chinese adult women for designing different types of skin-positioning membrane.MethodsThe radius of mammary glands in 236 cases of adult females was detected with color Doppler ultrasound at 5 different clock positions:12:00,3:00,6:00,9:00 and 10:30 or 1:30.SPSS 16.0 statistical software was used to analyze the data.The cut-off values of mammary glands radius at 99％,95％,75％ and 50％ were calculated.Paired t tests or nonparametric tests (relative sample rank sum tests) were used to verify the consistency of mammary gland radius between left and right sides.ResultsThe cut-off value of 95％ mammary gland radius was:7.700cm at 12:00,7.810 cm at 13:00,8.100 cm at 3:00,5.330 cm at 6:00 and 6.300 cm at 9:00 for left mammary gland ; 7.500 cm at 12:00,6.015 cm at 3:00,5.500 cm at 6:00,8.510 cm at 9:00 and 7.930 cm at 10:30 for right mammary gland.In comparison of left and right mammary gland radius,the difference had statistical significance between the group of left side at 1:30 and right side at 10:30,the group of left side at 3:00 and right side at 9:00(P ＜0.05).The right mamma was relatively larger.The cut-off values of the right mamma at the above two clock points were taken as radius of scale membranes while the average of percentage cut-off values at 12:00,3:00 of both mammas,left side at 9:00 and right side at 3:00 are taken as radius of scale membranes.ConclusionsAccording to the cut-off values of 99％,95％,75％ and 50％ radius of adult female mammary glands,mammary lump skin-positioning membrane radius can be classified into 4 size-types:extra large,large,medium and small.The precise classification of radius of mammary scale membranes according to mammary glands of adult females provides convenience for production,manufacture and clinical application of mammary lump skin-positioning membrane.
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Objective To observe the changes of cardiac function in liver cirrhosis decompensation stage.Methods This article reports the cardiac function changes of 32 cases liver cirrhosis patients in decompeusation stage as compared with 35 health persons.Some heart parameters are measured.Results In liver cirrhosis decompensation stage the EV of mitral valve and EV/AV in diastole function decreased significantly,the TEV of tricuspid valve decreased(P
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@#ObjectiveTo investigate the clinical characteristics and the way of discovery in early stage.Methods68 cases with asymptomatic pulmonary carcinoma living in Chongqing City who were discovered within health checkup were retrospectively analyzesed. ResultsThere were 62 males and 6 females,ages ranging from 28 to 78 years with an average of 52 years. In all patients,there were 56 cases (82.4%) with cigarette using history, 42 cases (61.8%) with family history of pulmonary carcinoma and 38 cases(55.9%) with cigarette using history and family history of pulmonary carcinoma. 65 cases (95.6%) were with peripheral type of lung cancer, 3 cases(4.4%) were with central type. Among these patients, 38 cases with adenocarcinoma ,18 cases with squamous carcinoma. There were 27 cases (39%) in Stage I, 38 cases(55.9%) in Stage II and 3 cases(4.4%) in Stage III. There were 43 cases (63.2%) without symptom while 25 cases(36.8%) with symptom of pulmonary carcinoma.ConclusionMost of patients with asymptomatic pulmonary carcinoma were middle-aged male and were adenocarcinoma or squamous carcinoma in cell type and had closed relationship with cigarette using history and family history.
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Objective To investigate the value of Tei index for estimating right ventricular global function in patients with dissymmetry hypertrophic cardiomyopathy(including obstructive and nonobstructive).Methods Pulsed wave Doppler of transtricuspid flow and transpulmonic valve flow were performed in hypertrophic obstructive cardiomyopathy(HOCM,n=28),hypertrophic nonobstructive cardiomyopathy(HNCM,n=34), and healthy control subjects(n=30) at apical four-chamber view and short-axis view of aortic root,and Tei index was calculated.Results~①Accelerating contraction time/right ventricular ejection time(ACT/RVET),isovolumetric contraction time(ICT),isovolumetric relaxation time(IRT),isovolumetric contraction time+isovolumetric relaxation time(ICT+IRT),right ventricular ejection time(RVET),ACT/RVET and Tei index[(ICT+IRT)/RVET] showed no significant changes between the groups of HOCM and HNCM.②Tei index was distinctly different between patients with HCM and control subjects(P